A smart ZnO@polydopamine-nucleic acid nanosystem for ultrasensitive live cell mRNA imaging by the target-triggered intracellular self-assembly of active DNAzyme nanostructures† †Electronic supplementary information (ESI) available: Oligonucleotide sequences, DLS and zeta potential measurements, TEM images, absorption and fluorescence spectra, cytotoxicity assay and CLSM images. See DOI: 10.1039/c6sc04633a Click here for additional data file.

A smart ZnO@polydopamine-nucleic acid nanosystem for ultrasensitive live cell mRNA imaging by the target-triggered intracellular self-assembly of active DNAzyme nanostructures.

Efficient strategies for the ultrasensitive imaging of gene expression in living cells are essential in chemistry and cell biology. Here, we report a novel and efficient enzyme-free dual signal amplification strategy for live cell mRNA imaging by using a smart nucleic acid hairpin-based nanosystem. This nanosystem consists of a ZnO nanoparticle core, an interlayer of polydopamine and an outer l...

A multi-functional PEGylated gold(iii) compound: potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery† †Electronic supplementary information (ESI) available: Experimental details, 1H NMR and MALDI-TOF-MS of 1 and 2; TEM image, DLS profile and zeta potential profile of 2; zeta potential profiles of 1 and NC1; cell viability profiles after treatment of the gold(iii) complexes and nanocomposites; total-ion chromatograms of UPLC-QTOF-MS of 1, 3 and 4; cellular uptake of the gold(iii) complexes; fluorescence microscopy images and flow cytometric analysis of the assay with FITC-Annexin V and propidium iodide; time-dependent fluorescence microscopy images and flow cytometric analysis of the assay using CellEvent™ Caspase-3/7 Green ReadyProbes Reagent; fluorescence microscopy images and flow cytometric analysis of the co-culture model of HCT116 and NCM460 cells; selected-ion chromatograms from UPLC-QTOF-MS of homogenized tumor tissues of mice treated by 1; biodistribution of gold complexes in nude mice bearing HCT116 xenografts; UPLC traces of the nanocomposites; tables showing the relative toxicities of the gold(iii) complexes and nanocomposites toward cancer cells over non-tumorigenic cells. See DOI: 10.1039/c6sc03210a Click here for additional data file.

Fig. S3 TEM image, DLS profile and profile showing the zeta potential of nanostructures of 2 in PBS solution • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • P.18 Fig. S4 Profiles showing the zeta potential of nanostructures of 1 and nanocomposite of 1...

Toward redesigning the PEG surface of nanocarriers for tumor targeting: impact of inner functionalities on size, charge, multivalent binding, and biodistribution† †Electronic supplementary information (ESI) available: Experimental section, tables, synthetic schemes, NMR and mass spectra, SAXS profiles, cytotoxicity assay results, confocal fluorescence micrographs, and SPECT images and movies. See DOI: 10.1039/c6sc05640g Click here for additional data file. Click here for additional data file. Click here for additional data file.

Semiconducting polymer dots with bright narrow-band emission at 800 nm for biological applications† †Electronic supplementary information (ESI) available: Materials and methods, 1H NMR and spectra of monomers, DLS, absorption and emission spectra of blended NIR800 Pdots, single particle fluorescence imaging. See DOI: 10.1039/c7sc00441a Click here for additional data file.

Department of Biomedical Engineering, Technology, Shenzhen, Guangdong 510855, Department of Chemistry and Bioenginee Washington 98195, USA. E-mail: chiu@chem State Key Laboratory on Integrated Optoele Engineering, Jilin University, Changchun, Jil † Electronic supplementary information ( H NMR and spectra of monomers, DLS blended NIR800 Pdots, single partic 10.1039/c7sc00441a ‡ These authors con...

A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy† †Electronic supplementary information (ESI) available: NMR spectra, ITC, UV-vis spectra, zeta potential, TEM and additional characterization data. See DOI: 10.1039/c5sc00994d Click here for additional data file.